Other treatable causes for heart failure like HT, CAD, AF have to be identified and treated.
Medications like ACEIs, ARBs, β blockers, MRA, which are useful in the treatment of HFrEF do not improve outcomes in HFpEF.
However careful assessment of volume overload, treatment with diuretics, small dose β-blocker and ARB are useful in reducing hospitalization in a minority of patients.
PARAGON-HF trial may give insight in the use of ARNI in the management of the same.
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